N, N'-Diacetyl-L-cystine

N, N'-Diacetyl-L-cystine is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N, N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits. N, N'-diacetyl-L-cystine is also an effective and orally active modulator of contact sensitivity/delayed-type hypersensitivity reactions in rodents. (In Vivo) :N, N'-Diacetyl-L-cystine (DiNAC; 0-973.11 μg/kg; p.o.; daily; for 12 weeks; WHHL rabbits) treatment decreases by 50% thoracic aorta atherosclerosis. However, it has no affecting plasma lipid levels.