Tradipitant
Tradipitant is an antagonist of neurokinin-1. (In Vitro) :Tradipitant binds to sections of guinea pig brain with a distribution similar to that previously reported for NK-1 receptors. Areas with the highest density are the accessory olfactory nucleus, anteroventral thalamic nucleus, paraventricular hypothalamic nucleus central amygdaloid nucleus (lateral), and the medial amygdaloid nucleus . (In Vivo) :Tradipitant (intravenously administered) treatment localizes in the guinea pig brain and has a distribution similar to that described for the NK-1 receptor using agonist or antagonist radioligands .
Product Specifications
CAS Number
622370-35-8
Product Name Alternative
VLY-686 | LY686017
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (170.10 mM)
Smiles
FC (F) (F) c1cc (Cn2nnc (c2-c2ccncc2) -c2ncccc2C (=O) c2ccccc2Cl) cc (c1) C (F) (F) F
Molecular Formula
C28H16ClF6N5O
Molecular Weight
587.91
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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