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Ataciguat

Ataciguat (HMR-1766) is a potent and specific soluble guanylate cyclase (sGC) activator. (In Vitro) :Ataciguat induces the relaxation in aortic rings or coronary rings. In the presence of nitric oxide synthase (NOS) inhibitor, the endothelium effect was abolished to DETA-NO or ataciguat, in both vessels. Ataciguat was able to induce NO production in HUVECs cells. In the presence of NOS inhibitor, the NO production induced by ataciguat was abolished.

Product Specifications

CAS Number

254877-67-3

Product Name Alternative

HMR-1766

Purity

>98% (HPLC)

Solubility

In Vitro: DMSO : 100 mg/mL (173.46 mM)

Smiles

Clc1ccc (s1) S (=O) (=O) Nc1ccc (Cl) cc1C (=O) Nc1ccc (cc1) S (=O) (=O) N1CCOCC1

Molecular Formula

C21H19Cl2N3O6S3

Molecular Weight

576.48

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

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