Ononetin
Ononetin is a TRPM3 channel blocker (IC50: 0.3 μM) . (In Vitro) :Administration of 1-10 μM Ononetin completely and reversibly abrogates Ca2+ entry and ionic currents through recombinantly expressed TRPM3α2 and block the pregnenolone sulphate-inducible Ca2+ entry in primary cultures of mouse or rat dorsal root ganglia (DRG) neurones. (In Vivo) :Intraperitoneal injection of 10 mg/kg Ononetin completely reverses established Freund's Complete Adjuvant (FCA) -induced heat hypersensitivity, demonstrating that the loss of hypersensitivity in Trpm3-/- mice is unlikely to be caused by developmental or compensatory mechanisms.
Product Specifications
CAS Number
487-49-0
Product Name Alternative
2',4'-Dihydroxy-2- (4-methoxyphenyl) acetophenone
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (387.19 mM)
Smiles
COc1ccc (CC (=O) c2ccc (O) cc2O) cc1
Molecular Formula
C15H14O4
Molecular Weight
258.273
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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