3-Deazauridine
3-Deazauridine is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase which is considered to be the primary mode of action of this nucleoside analog. (In Vitro) :3-Deazauridine enhanced the in vitro antineoplastic action of 5-AZA-CdR on human leukemic cells by increasing its incorporation into DNA. Using an optimized dose-schedule we showed that this combination could cure some mice bearing L1210 leukemia, even in the presence of a subpopulation of drug-resistant (L1210/ARA-C) leukemic cells lacking DCK. 3-Deazauridine alone also cured some mice with L1210/ARA-C leukemia.
Product Specifications
CAS Number
23205-42-7
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (411.17 mM)
Smiles
OC[C@H]1O[C@H] ([C@H] (O) [C@@H]1O) n1ccc (O) cc1=O
Molecular Formula
C10H13NO6
Molecular Weight
243.215
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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