PD-1/PD-L1-IN-14
PD-1/PD-L1-IN-14 (compound 17) is a bifunctional inhibitor of PD-1/PD-L1 interactions, with an IC50 of 27.8 nM. PD-1/PD-L1-IN-14 (compound 17) inhibits PD-1/PD-L1 interactions and promotes dimerization, internalization, and degradation of PD-L1[1].
Product Specifications
CAS Number
2499965-12-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pd-1-pd-l1-in-14.html
Purity
99.60
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 160°C)
Smiles
CC1=C(C2=NN=C(NC3=CC(CNCCO)=CC=C3)O2)C=CC=C1C4=CC=CC=C4
Molecular Formula
C24H24N4O2
Molecular Weight
400.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Tianyu Wang, et al. Discovery of Small-Molecule Inhibitors of the PD-1/PD-L1 Axis That Promote PD-L1 Internalization and Degradation. J Med Chem. 2022 Mar 10;65 (5) :3879-3893.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
46701151 3x 1.0 µg DNA
TIGD6 CRISPR All-in-one AAV vector set (with saCas9)(Human)
Sign In for Pricing
View Details 
