PD-1/PD-L1-IN-14

PD-1/PD-L1-IN-14 (compound 17) is a bifunctional inhibitor of PD-1/PD-L1 interactions, with an IC50 of 27.8 nM. PD-1/PD-L1-IN-14 (compound 17) inhibits PD-1/PD-L1 interactions and promotes dimerization, internalization, and degradation of PD-L1[1].

Product Specifications

CAS Number

[2499965-12-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PD-1/PD-L1

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pd-1-pd-l1-in-14.html

Purity

99.60

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 160°C)

Smiles

CC1=C(C2=NN=C(NC3=CC(CNCCO)=CC=C3)O2)C=CC=C1C4=CC=CC=C4

Molecular Formula

C24H24N4O2

Molecular Weight

400.47

Precautions

H302, H315, H319, H335

References & Citations

[1]Tianyu Wang, et al. Discovery of Small-Molecule Inhibitors of the PD-1/PD-L1 Axis That Promote PD-L1 Internalization and Degradation. J Med Chem. 2022 Mar 10;65 (5) :3879-3893.