Zapnometinib
Zapnometinib is a MEK inhibitor. (In Vitro) :Zapnometinib inhibits MEK, with IC50s of 30.96 nM, 357 nM, and 15 nM in cell free kinase assay, A549, MDCK cells and human PBMCs.Zapnometinib reduces the viral titers of the IV H1N1pdm09, H3N2. (In Vivo) :Zapnometinib exhibits AUC values of 860.02 and 1953.68 μg h/mL in mice by i.v. or oral route, respectively.Zapnometinib reduces the lung virus titers and enhances survival of mice after lethal H1N1pdm09 infection.
Product Specifications
CAS Number
303175-44-2
Product Name Alternative
2- (2-chloro-4-iodoanilino) -3,4-difluorobenzoic acid | PD0184264 | ATR-002
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 62.5 mg/mL (152.61 mM)
Smiles
OC (c (c (Nc (ccc (I) c1) c1Cl) c1F) ccc1F) =O
Molecular Formula
C13H7ClF2INO2
Molecular Weight
409.55
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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