FR054
FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect. FR054 induces in different breast cancer cells a dramatic decrease in cell proliferation and survival. (In Vivo) :The effect of FR054 occurs through PGM3 inhibition instead of other off-target effects. FR054 (0.5-1 mM, 24-48 h) induces an early proliferation arrest followed by a marked cell death increase in breast cancer cells and induces apoptosis. FR054 (250 μM, 24 h) treatment efficiently affects both N- and O-glycosylation levels in MDA-MB-231 cells. FR054 induces endoplasmic reticulum stress and ROS-dependent apoptotic cell death .
Product Specifications
CAS Number
35954-65-5
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (303.67 mM)
Smiles
CC (OC[C@H] ([C@H]1OC (C) =O) O[C@@H]2OC (C) =N[C@@H]2[C@H]1OC (C) =O) =OCC (OC[C@H] ([C@H]1OC (C) =O) O[C@@H]2OC (C) =N[C@@H]2[C@H]1OC (C) =O) =O
Molecular Formula
C28H37N2O16
Molecular Weight
657.6
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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