Sinapyl alcohol

Technical grade is a natural from Magnolia sieboldii. (In Vitro) :Sinapyl alcohol more potently inhibited lipopolysaccharide (LPS) -induced nitric oxide (NO), prostaglandin E2 (PGE2), and tumor necrosis factor (TNF) -α production by macrophages than syringin. Consistent wih thse observations, the expression levels of inducible NO synthase (iNOS) and cyclooxygenase (COX) -2 was reduced by sinapyl alcohol in a concentration-dependent manner. (In Vivo) :Sinapyl alcohol (20,30mg/kg/day, p.o.) inhibited increased vascular permeability by acetic acid in mice and reduced acute paw edema by carrageenan in rats more so tan syringin.