ZINC77292789
Fmoc-Thr[GalNAc (Ac) 3-α-D]-OH is a reagent for the preparation of a synthetic MUC1 Glycopeptide Bearing βGalNAc- Thr as a Tn antigen isomer which induces the antibody production against tumor cells. Fmoc-Thr[GalNAc (Ac) 3-α-D]-OH is a starting material to make trimeric MUC1 immunodominant motif antigen- based anti- cancer vaccine candidates. (In Vitro) :The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (Tn antigen) .
Product Specifications
CAS Number
116783-35-8
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : ≥ 100 mg/mL (149.11 mM)
Smiles
C[C@H] ([C@@H] (C (O) =O) NC (OCC1c (cccc2) c2-c2c1cccc2) =O) O[C@H] ([C@@H] ([C@H]1OC (C) =O) NC (C) =O) O[C@H] (COC (C) =O) [C@@H]1OC (C) =O
Molecular Formula
C33H38N2O13
Molecular Weight
670.66
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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