ZINC77292789

Fmoc-Thr[GalNAc (Ac) 3-α-D]-OH is a reagent for the preparation of a synthetic MUC1 Glycopeptide Bearing βGalNAc- Thr as a Tn antigen isomer which induces the antibody production against tumor cells. Fmoc-Thr[GalNAc (Ac) 3-α-D]-OH is a starting material to make trimeric MUC1 immunodominant motif antigen- based anti- cancer vaccine candidates. (In Vitro) :The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (Tn antigen) .