(S) - (-) -Bay-K-8644
(S) - (-) -Bay-K-8644 is an agonist of L-type Ca2+ channel and activates Ba2+ currents with an EC50 of 32 nM. (In Vitro) :The Ca2+ channel activity is enhanced by 3–30 μM (S) - (-) -Bay-K-8644 an agonist of L-type Ca2+ channels . FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by (S) - (-) -Bay-K-8644 (EC50: 14 nM) . (S) - (-) -Bay-K-8644 (100 nM) increases whole-cell Ca2+ currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176 . (S) - (-) -Bay-K-8644 can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on IBa in gastric myocytes of the guinea pig antrum.
Product Specifications
CAS Number
98625-26-4
Product Name Alternative
(S) - (-) -Bay K 8644
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (280.66 mM)
Smiles
COC (=O) C1=C (C) NC (C) =C ([C@H]1c1ccccc1C (F) (F) F) [N+] ([O-]) =O
Molecular Formula
C16H15F3N2O4
Molecular Weight
356.301
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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