(S) - (-) -Bay-K-8644

(S) - (-) -Bay-K-8644 is an agonist of L-type Ca2+ channel and activates Ba2+ currents with an EC50 of 32 nM. (In Vitro) :The Ca2+ channel activity is enhanced by 3–30 μM (S) - (-) -Bay-K-8644 an agonist of L-type Ca2+ channels . FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by (S) - (-) -Bay-K-8644 (EC50: 14 nM) . (S) - (-) -Bay-K-8644 (100 nM) increases whole-cell Ca2+ currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176 . (S) - (-) -Bay-K-8644 can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on IBa in gastric myocytes of the guinea pig antrum.