LUNA18
LUNA18 is an 11-mer cyclic peptide inhibitor for the intracellular tough target RAS with Kd (KRAS/G12D) of 0.043 nM and cellular IC50 of 1.4 nM (AsPC-1) . LUNA18 orally and dose-dependently exhibits potent anti-cancer activities in a mouse xenograft model. LUNA18 shows 21–47% oral bioavailability in animals such as mouse, rat, monkey, and dog and notably does not require special formulations.
Product Specifications
Purity
0.98
Smiles
O=C (N (C) C) C[C@@H] (C (N (C) [C@@H] (CC (C) C) C (N[C@@H] ([C@@H] (C) CC) C (N (C) [C@H]1C) =O) =O) =O) N (C) C ([C@H] (C2CCCC2) N (C) C (C3 (CCCC3) NC ([C@@] (CCC4) ([H]) N4C ([C@H] (CCC5=CC (F) =C (C (F) (F) F) C (F) =C5) NC (CN (C) C ([C@H] (CC6=CC=C (C) C=C6) N (CC) C ([C@@] (CC7) ([H]) N7C1=O) =O) =O) =O) =O) =O) =O) =O
Molecular Formula
C73H105F5N12O12
Molecular Weight
1437.71
Notes
For research use only.
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