XD2-149
XD2-149 is a napabucasin PROTAC as an effective degrader of the E3 ligase ZFP91 with IC50 of 1 μM and 0.8 μM in pancreatic cancer cell lines, MIA PaCa-2 and BxPC-3, respectively. XD2-149 also reduces the expression of STAT3, pSTAT3, and NQO1 proteins.
Product Specifications
Purity
>98%
Smiles
O=C (CC1) NC (C1N (C2=O) C (C3=C2C (NCCCCCC (CC4) CCN4CCNC (C (O5) =CC6=C5C (C7=C (C6=O) C=CC=C7) =O) =O) =CC=C3) =O) =O
Molecular Formula
C38H39N5O8
Molecular Weight
693.757
Notes
For research use only.
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