WRX606
WRX606 is a nonrapalog inhibitor. WRX606 formed a ternary complex with FK506-binding protein-12 (FKBP12) and FKBP−rapamycin-binding (FRB) domain of mTOR, resulting in the allosteric inhibition of mTORC1. WRX606 inhibited the phosphorylation of not only the ribosomal protein S6 kinase 1 (S6K1) but also eIF4E-binding protein-1 (4E-BP1) . Hence, WRX606 efficiently suppressed tumor growth in mice without promotion of metastasis. These results suggest that WRX606 is a potent lead compound for developing anticancer drugs discovered by in silico and in cell methods.
Product Specifications
CAS Number
899937-47-4
Purity
>98%
Smiles
N1 (CC (NC2=CC=CC (Cl) =C2) =O) C2=C (C=CC=C2) C (=O) N (CCCC (NCC2=CC=C3OCOC3=C2) =O) C1=O
Molecular Formula
C28H25CLN4O6
Molecular Weight
548.974305868149
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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