GAT1508
GAT1508 (GAT-1508) is a potent, specific activator for brain-expressed GIRK1/2 channels (EC50=75 nM), specifically activates the brain GIRK1/2 over the cardiac GIRK1/4; GAT1508 is an allosteric modulator of channel–phosphatidylinositol 4,5-bisphosphate interactions. GAT1508 effectively extinguished conditioned fear in rodents and lacked cardiac and behavioral side effects, suggesting its potential for use in pharmacotherapy for post-traumatic stress disorder.
Product Specifications
CAS Number
2397594-21-5
Purity
The purity of the compound is 98%
Smiles
C1=CC=CC (N2N=C (C=C2NC (=O) NC2SC (Br) =CC=2) C) =C1
Molecular Formula
C15H13BrN4OS
Molecular Weight
377.258
Storage Conditions
Store at -20°C (desiccating conditions) .
Notes
For research use only.
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