L-Leucine-d2

L-Leucine-d2 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

Product Specifications

CAS Number

[362049-59-0]

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Endogenous Metabolite; mTOR

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Purity

99.0

Solubility

H2O : 12.5 mg/mL (ultrasonic)

Smiles

CC(C)C([2H])([2H])[C@H](N)C(O)=O

Molecular Formula

C6H11D2NO2

Molecular Weight

133.19

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9 (10) :e1003857.|[3]Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond) . 2012 Aug 22;9 (1) :77.|[4]Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61 (2) :409-17.