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4-Octyl itaconate

4-Octyl Itaconate is a cell-permeable Itaconate derivative. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1[1].

Product Specifications

CAS Number

3133-16-2

Product Name Alternative

4-OI

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Keap1-Nrf2

Type

Reference compound

Related Pathways

NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/4-octyl-itaconate.html

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(OCCCCCCCC)CC(C(O)=O)=C

Molecular Formula

C13H22O4

Molecular Weight

242.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Mills EL, et al. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature. 2018 Apr 5;556 (7699) :113-117.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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