4-Octyl itaconate
4-Octyl Itaconate is a cell-permeable Itaconate derivative. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1[1].
Product Specifications
CAS Number
[3133-16-2]
Product Name Alternative
4-OI
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/4-octyl-itaconate.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OCCCCCCCC)CC(C(O)=O)=C
Molecular Formula
C13H22O4
Molecular Weight
242.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Mills EL, et al. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature. 2018 Apr 5;556 (7699) :113-117.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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