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Propargyl-PEG4-acid

Propargyl-PEG4-acid is a polyethylene glycol (PEG) linker utilized in constructing PROTAC molecules, such as BTK-targeting degraders derived from Ibrutinib. For instance, a related PROTAC 3 degrades Bruton's Tyrosine Kinase (BTK) with a DC50 of 200 nM in THP-1 cell-based assays, demonstrating its application in targeted protein degradation research.

Product Specifications

CAS Number

1415800-32-6

Field of Research

Pharmacology & Drug Discovery

Smiles

C (OCCOCCOCC#C) COCCC (O) =O

Molecular Formula

C12H20O6

Molecular Weight

260.28

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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