Propargyl-PEG4-CH2CH2-Boc

This non-cleavable ADC linker, featuring a propargyl handle and a Boc-protected amine, is built on a flexible PEG-alkyl ether scaffold. It is utilized in bioconjugation for constructing antibody-drug conjugates (ADCs) and has been applied in the synthesis of inhibitors targeting Galectin-3 for cancer research in both in vitro and in vivo studies.