SC144 hydrochloride

SC144 hydrochloride is a first-in-class, orally bioavailable small molecule inhibitor targeting gp130 (IL6ST) . It blocks ligand-induced gp130 signaling, STAT3 activation, and downstream gene expression, effectively inducing apoptosis in human ovarian cancer cells in vitro. Its research applications extend to studying oncogenic signaling and therapeutic potential in various cancers.