Poseltinib
Poseltinib is a potent, selective, and irreversible BTK inhibitor (IC50=1.95 nM) that covalently targets Cys481. It exhibits high selectivity over related kinases and blocks key signaling pathways. This inhibitor is widely used in research for studying autoimmune diseases and B-cell malignancies in both cellular and animal models.
Product Specifications
CAS Number
1353552-97-2
Product Name Alternative
HM 71224, HM71224, LY3337641, LY 3337641, Poseltinib
Field of Research
Cardiovascular Research, Immunology & Inflammation, Signal Transduction
Purity
99.98% (May vary between batches)
Solubility
DMSO:80 mg/mL (170.02 mM)
Smiles
O=C (C=C) NC=1C=CC=C (OC2=NC (=NC=3C=COC23) NC4=CC=C (C=C4) N5CCN (C) CC5) C1
Molecular Formula
C26H26N6O3
Molecular Weight
470.52
Storage Conditions
-20°C
Notes
For research use only.
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