Branaplam hydrochloride
Branaplam hydrochloride (LMI070) is an orally active, selective SMN2 splicing modulator with an EC50 of 20 nM for SMN. It also inhibits hERG channels (IC50 = 6.3 μM) . In vivo, it elevates full-length SMN protein and improves survival in severe SMA mouse models, supporting its research in spinal muscular atrophy.
Product Specifications
CAS Number
1562338-39-9
Product Name Alternative
LMI 070 hydrochloride, LMI070 hydrochloride, NVS-SM1 hydrochloride
Field of Research
Cell Biology, Molecular Biology, Pharmacology & Drug Discovery
Purity
98.45% (May vary between batches)
Solubility
H2O:<1mg/mL (Insoluble) ; DMSO:200 mg/mL (465.17 mM)
Smiles
Cl.OC1=CC (=CC=C1C=2N=NC (OC3CC (NC (C) (C) C3) (C) C) =CC2) C=4C=NNC4
Molecular Formula
C22H28ClN5O2
Molecular Weight
429.95
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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