Formosanin C

Formosanin C is a diosgenin saponin with multiple biological activities. Formosanin C possesses multiple anti-tumor mechanisms, including inducing apoptosis and autophagy, blocking the cell cycle, inhibiting metastasis and inducing ferroptosis. Formosanin C can inhibit the NF-κB signaling pathway to exert anti-inflammatory effects, and enhance the activity of immune cells. Formosanin C exhibits the inhibiting effect against C. albicans. Formosanin C can be used for the study of anti-inflammation, antifungal anti and anti-cancer (including lung cancer, liver cancer, breast cancer and colorectal cancer, etc.) [1][2][3][4][5][6].

Product Specifications

CAS Number

[50773-42-7]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Autophagy; Ferroptosis; Fungal; NF-κB

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/formosanin-c.html

Purity

99.28

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@]3([H])[C@](O[C@]4(CC[C@@H](C)CO4)[C@H]3C)([H])C[C@@]1([H])[C@@]5([H])[C@]([C@@]6(C(C[C@@H](O[C@@]7([H])[C@@H]([C@H]([C@H](O[C@@]8([H])[C@@H]([C@@H]([C@@H](O[C@@]9([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O9)O)O)[C@H](C)O8)O)O)[C@@H](CO)O7)O)O[C@@]%10([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O%10)O)O)CC6)=CC5)C)([H])CC2

Molecular Formula

C51H82O20

Molecular Weight

1015.18

Precautions

H302

References & Citations

[1]Wu RT, et al. Formosanin-C, an immunomodulator with antitumor activity. Int J Immunopharmacol. 1990;12 (7) :777-86.|[2]Li Y, et al. The antitumor effect of formosanin C on HepG2 cell as revealed by 1H-NMR based metabolic profiling. Chem Biol Interact. 2014 Sep 5;220:193-9.|[3]Chu ML, et al. Formosanin C suppresses cancer cell proliferation and migration by impeding autophagy machinery. Kaohsiung J Med Sci. 2023 May;39 (5) :489-500. |[4]Lin PL, et al. Saponin Formosanin C-induced Ferritinophagy and Ferroptosis in Human Hepatocellular Carcinoma Cells. Antioxidants (Basel) . 2020 Jul 29;9 (8) :682.|[5]Yin L, et al. Formosanin C attenuates lipopolysaccharide-induced inflammation through nuclear factor-κB inhibition in macrophages. Korean J Physiol Pharmacol. 2021 Sep 1;25 (5) :395-401. |[6]Dorsaz S, et al. Identification and Mode of Action of a Plant Natural Product Targeting Human Fungal Pathogens. Antimicrob Agents Chemother. 2017 Aug 24;61 (9) :e00829-17.