Streptozotocin

Streptozotocin (Streptozocin; STZ) is an antibiotic widely used in experimental animal models of induced diabetes. Streptozotocin enters B cells via the glucose transporter (GLUT2) and causes the alkylation of DNA (DNA-methylating) . Streptozotocin can induce the apoptosis of β cells[1][2][3].

Product Specifications

CAS Number

[18883-66-4]

Product Name Alternative

Streptozocin; NSC-85998; U 9889

UNSPSC

12352005

Hazard Statement

H228, H341, H351

Target

Antibiotic; Apoptosis; Autophagy; Bacterial; DNA Alkylator/Crosslinker; DNA/RNA Synthesis

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/streptozotocin.html

Purity

99.20

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](NC(N(C)N=O)=O)[C@H]1O

Molecular Formula

C8H15N3O7

Molecular Weight

265.22

Precautions

H228, H341, H351

References & Citations

[1]Furman BL. Streptozotocin-Induced Diabetic Models in Mice and Rats. Curr Protoc Pharmacol. 2015 Sep 1;70:5.47.1-5.47.20.|[2]Bennett RA, et al. Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 1981 Jul;41 (7) :2786-90.|[3]Kim B, et al. Outbred Mice with Streptozotocin-Induced Diabetes Show Sex Differences in Glucose Metabolism. Int J Mol Sci. 2023 Mar 8;24 (6) :5210.|[4]Gurley SB, et al. Impact of genetic background on nephropathy in diabetic mice. Am J Physiol Renal Physiol. 2006 Jan;290 (1) :F214-22.|[5]Huang F, et al. Antidiabetic effect of a new peptide from Squalus mitsukurii liver (S-8300) in streptozocin-induced diabetic mice. J Pharm Pharmacol. 2005 Dec;57 (12) :1575-80.|[6]Diab RA, et al. Immunotoxicological effects of streptozotocin and alloxan: in vitro and in vivo studies. Immunol Lett. 2015 Feb;163 (2) :193-8.|[7]Raza H, et al. Streptozotocin-induced cytotoxicity, oxidative stress and mitochondrial dysfunction in human hepatoma HepG2 cells. Int J Mol Sci. 2012;13 (5) :5751-5767.|[8]Schnedl WJ, et al. STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells. Diabetes. 1994 Nov;43 (11) :1326-33.