GRK6-IN-2

GRK6-IN-2 (compound 10a) is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-2 has the potential for the research of multiple myeloma[1].

Product Specifications

CAS Number

[2677786-27-3]

UNSPSC

12352005

Target

G Protein-coupled Receptor Kinase (GRK)

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/grk6-in-2.html

Purity

98.98

Solubility

DMSO : ≥ 100 mg/mL

Smiles

C[C@H](NC1=NC(NC2=NNC(CC)=C2)=C3C=CC=CC3=N1)C4=CC=C(F)C=C4

Molecular Formula

C21H21FN6

Molecular Weight

376.43

References & Citations

[1]Uehling DE, et al. Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma [published correction appears in J Med Chem. 2022 Jan 13;65 (1) :886-887]. J Med Chem. 2021;64 (15) :11129-11147.