N2-Isobutyryl-7'-OH-N-DMTr-morpholino guanine

This compound is a morpholino nucleoside derivative featuring an N2-isobutyryl and 7'-hydroxy protecting group, with a dimethoxytrityl (DMTr) group on the morpholino nitrogen. It serves as a key phosphoramidite precursor in the solid-phase synthesis of morpholino antisense oligonucleotides, which are used in vitro and in vivo to modulate gene expression.