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PF-03463275

PF-03463275 is a potent, brain-penetrant, and selective reversible inhibitor of the glycine transporter 1 (GlyT1) with a Ki of 11.6 nM. It is utilized in neuroscience research to investigate the modulation of NMDA receptor function and has been studied in preclinical models for its potential to address cognitive impairments in schizophrenia.

Product Specifications

CAS Number

1173239-39-8

Product Name Alternative

GlyT1, PF 03463275, PF 3463275, PF03463275, PF-03463275, PF-3463275, PF3463275

Field of Research

Neuroscience

Purity

99.86% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (2.65 mM) ; DMSO:30 mg/mL (79.61 mM)

Smiles

[H][C@@]12CN (C) C[C@]1 ([H]) [C@H]2CN (Cc1ccc (F) c (Cl) c1) C (=O) c1cn (C) cn1

Molecular Formula

C19H22ClFN4O

Molecular Weight

376.86

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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