Clinofibrate

Clinofibrate (S-8527) is a hypelipidemic agent and a HMG-CoA reductase inhibitor.

Product Specifications

CAS Number

[30299-08-2]

Product Name Alternative

S-8527

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; HMG-CoA Reductase (HMGCR)

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Clinofibrate.html

Concentration

10mM

Purity

98.54

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

CCC(OC1=CC=C(C2(C3=CC=C(OC(CC)(C)C(O)=O)C=C3)CCCCC2)C=C1)(C)C(O)=O

Molecular Formula

C28H36O6

Molecular Weight

468.58

Precautions

H302, H315, H319, H335

References & Citations

[1]Okazaki M, et al. Effects of clinofibrate on plasma fibrinogen level in high fructose diet-induced hyperlipidemic rats. In Vivo. 1994 Nov-Dec;8 (6) :1057-61.|[2]Shirai K, et al. Effect of clinofibrate on lipid metabolism of aorta in atherosclerotic rats. Artery. 1983;12 (3) :145-55.|[3]Suzuki K, et al. Effects of S-8527 (1,1-bis4'- (1"-carboxy'1"-methylpropoxy) -phenyl) -cyclohexane), a new hypolipidemic compound, on triglyceride metablolism in rats. Biochem Pharmacol. 1975 Jun 15;24 (11-12) :1203-7.|[4]Suzuki K, et al. Hypolipidemic effect of a new aryloxy compound, S-8527, in experimental animals. Jpn J Pharmacol. 1974 Jun;24 (3) :407-14.