JBSNF-000028 (TFA)
JBSNF-00002 TFA is an orally active small molecule inhibitor of the tricyclic nicotinamide N-methyltransferase (NNMT) with IC50 values for human, mouse and monkey sources of NNMT of 33, 210 and 190 nM respectively. JBSNF-00002 TFA can reduce endogenous MNA levels in U2OS osteosarcoma cells, with its EC50 being 2.5 μM. JBSNF-00002 TFA exhibits significant anti-obesity and anti-diabetic activities in the diet-induced obesity (DIO) model. JBSNF-00002 TFA can be used for the study of metabolic diseases such as obesity, type 2 diabetes and non-alcoholic fatty liver disease[1].
Product Specifications
UNSPSC
12352005
Target
Amine N-methyltransferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/jbsnf-000028-tfa.html
Concentration
10mM
Purity
99.47
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CN1CC2=C3C(CCN3C1=N)=CC=C2.FC(F)(C(O)=O)F
Molecular Formula
C13H14F3N3O2
Molecular Weight
301.26
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
CD106 / VCAM1 (B-K9), CF594 conjugate, 0.1mg/mL
CD45 / LCA (2B11 + PD7/26), CF640R conjugate, 0.1mg/mL
Eosinophil Peroxidase (AHE-1), CF647 conjugate, 0.1mg/mL
