Icopezil
Icopezil is a small molecule acetylcholinesterase (AChE) inhibitor used in neuroscience research. It serves as a tool compound for investigating cholinergic function in models of Alzheimer's disease and other neurological disorders, applicable in both in vitro enzymatic assays and in vivo behavioral studies.
Product Specifications
CAS Number
145508-78-7
Product Name Alternative
AChE
Field of Research
Neuroscience
Purity
98.16% (May vary between batches)
Solubility
DMSO:50 mg/mL (133.17 mM)
Smiles
C (CC1CCN (CC2=CC=CC=C2) CC1) C=3C4=C (C=C5C (=C4) CC (=O) N5) ON3
Molecular Formula
C23H25N3O2
Molecular Weight
375.46
References & Citations
Ye Bin Shin 1, Jin Hwan Kim 1, Min Kyeong Kwon 1, Jin Hyuk Myung 1, Dong Geon Lee 1, Sung Giu Jin 2, Myung Joo Kang 1, Yong Seok Choi Optimized method development and validation for determining donepezil in rat plasma: A liquid-liquid extraction, LC-MS/MS, and design of experiments approach PLoS One, (2024), Min Young Jeong et al. Coupling syringe system comprising drug nanosuspension and photo-crosslinked gelatin methacryloyl hydrogel for subcutaneous delivery with decreased initial exposure Materials & Design, (2025)
Pubmed id
39240870
Storage Conditions
-20°C
Notes
For research use only.
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