PU-H71
PU-H71 is a potent and selective HSP90 inhibitor, demonstrating an IC50 value of 51 nM. It is widely used in cancer research to study oncogenic client protein degradation in both cellular and animal models of various malignancies.
Product Specifications
CAS Number
873436-91-0
Product Name Alternative
HSP90, PU H71, PUH71, PU-H71
Field of Research
Metabolism Research, Signal Transduction
Purity
98.02% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.9 mM) ; DMSO:46.1 mg/mL (89.97 mM)
Smiles
CC (C) NCCCn1c (Sc2cc3OCOc3cc2I) nc2c (N) ncnc12
Molecular Formula
C18H21IN6O2S
Molecular Weight
512.37
References & Citations
Romy Cools # 1, Valeria Narykina # 1 2 3, Koen Vermeulen 4, Sanket J Mishra 5, Brian S J Blagg 5 6, Marleen Derweduwe 7 8 9, Frederik De Smet 7 8 9, Aaron Ziani-Zeryouh 10, Matteo Riva 10 11, An Coosemans 10, Frederic Rousseau 2 3, Joost Schymkowitz 2 3, Guy Bormans 12 [11C]HSP990 PET as a translational tool to investigate the role of Hsp90 in tumours and support the development of Hsp90 therapeutics EJNMMI Radiopharm Chem, (2025)
Pubmed id
41003947
Storage Conditions
-20°C
Notes
For research use only.
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