Zelavespib HCl
PU-H71 HCl (Zelavespib HCl) is a purine-scaffold Hsp90 inhibitor and radiosensitizer with demonstrated antitumor activity in preclinical models. It impairs DNA double-strand break repair by downregulating key proteins like Rad51 and Ku70, relevant to homologous recombination and non-homologous end joining pathways. Its efficacy has been studied in various in vitro and in vivo cancer models.
Product Specifications
CAS Number
2095432-24-7
Product Name Alternative
DNA Synthesis, DNASynthesis, HSP90, RNA Synthesis, RNASynthesis, PU-H71 HCl, PU-H71 HCl (873436-91-0 Free base), RAD51, Zelavespib HCl
Field of Research
Cell Biology, Metabolism Research, Molecular Biology, Signal Transduction
Purity
98.00% (May vary between batches)
Solubility
DMSO:45 mg/mL (81.99 mM)
Smiles
Cl.IC=1C=C2OCOC2=CC1SC3=NC=4C (=NC=NC4N3CCCNC (C) C) N
Molecular Formula
C18H22ClIN6O2S
Molecular Weight
548.83
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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