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AOH1996

AOH1996 is an orally bioavailable PCNA-targeting ligand that disrupts transcription-replication conflicts. It stabilizes PCNA-RNA polymerase II interactions, inducing proteasomal degradation of RPB1, DNA damage, and apoptosis. This molecule shows synergistic activity with genotoxic agents in preclinical cancer models, providing a research tool for studying replication stress and combination therapies.

Product Specifications

CAS Number

2089314-64-5

Product Name Alternative

DNA, AOH 1996, AOH1996, AOH-1996, apoptosis, PCNA

Field of Research

Cell Biology, Molecular Biology

Purity

98.17% (May vary between batches)

Solubility

DMSO:250 mg/mL (586.22 mM)

Smiles

C (NCC (NC1=C (OC2=CC (OC) =CC=C2) C=CC=C1) =O) (=O) C=3C4=C (C=CC3) C=CC=C4

Molecular Formula

C26H22N2O4

Molecular Weight

426.46

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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