AOH1996
AOH1996 is an orally bioavailable PCNA-targeting ligand that disrupts transcription-replication conflicts. It stabilizes PCNA-RNA polymerase II interactions, inducing proteasomal degradation of RPB1, DNA damage, and apoptosis. This molecule shows synergistic activity with genotoxic agents in preclinical cancer models, providing a research tool for studying replication stress and combination therapies.
Product Specifications
CAS Number
2089314-64-5
Product Name Alternative
DNA, AOH 1996, AOH1996, AOH-1996, apoptosis, PCNA
Field of Research
Cell Biology, Molecular Biology
Purity
98.17% (May vary between batches)
Solubility
DMSO:250 mg/mL (586.22 mM)
Smiles
C (NCC (NC1=C (OC2=CC (OC) =CC=C2) C=CC=C1) =O) (=O) C=3C4=C (C=CC3) C=CC=C4
Molecular Formula
C26H22N2O4
Molecular Weight
426.46
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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