JC2-11
JC2-11 is a small molecule inhibitor that suppresses inflammasome activation by targeting NLRC4 and AIM2 pathways. It disrupts ROS production and caspase-1 activity, thereby reducing GSDMD cleavage, IL-1β maturation, and LDH release. This compound is a valuable research tool for studying pyroptosis and inflammation in both cellular and animal models of inflammatory diseases.
Product Specifications
CAS Number
937820-89-8
Product Name Alternative
LDH, NODlikeReceptor (NLR), NODlikeReceptor, NOD-like Receptor (NLR), NOD-like Receptor, NODlike Receptor (NLR), NLR, JC211, JC2-11, IL Receptor, IL-1β, ILReceptor, Caspase-1, AIM2, ROS
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research, Protein Biochemistry
Purity
98.60% (May vary between batches)
Solubility
DMSO:127.5 mg/mL (421.77 mM)
Smiles
C (/C=C/C1=CC (OC) =C (O) C=C1) (=O) C2=CC (F) =C (OC) C=C2
Molecular Formula
C17H15FO4
Molecular Weight
302.3
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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