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JC2-11

JC2-11 is a small molecule inhibitor that suppresses inflammasome activation by targeting NLRC4 and AIM2 pathways. It disrupts ROS production and caspase-1 activity, thereby reducing GSDMD cleavage, IL-1β maturation, and LDH release. This compound is a valuable research tool for studying pyroptosis and inflammation in both cellular and animal models of inflammatory diseases.

Product Specifications

CAS Number

937820-89-8

Product Name Alternative

LDH, NODlikeReceptor (NLR), NODlikeReceptor, NOD-like Receptor (NLR), NOD-like Receptor, NODlike Receptor (NLR), NLR, JC211, JC2-11, IL Receptor, IL-1β, ILReceptor, Caspase-1, AIM2, ROS

Field of Research

Cell Biology, Immunology & Inflammation, Metabolism Research, Protein Biochemistry

Purity

98.60% (May vary between batches)

Solubility

DMSO:127.5 mg/mL (421.77 mM)

Smiles

C (/C=C/C1=CC (OC) =C (O) C=C1) (=O) C2=CC (F) =C (OC) C=C2

Molecular Formula

C17H15FO4

Molecular Weight

302.3

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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