TNKS-2-IN-1
TNKS-2-IN-1 is a dual inhibitor of tankyrase 1 and 2 (IC50s: 259 nM and 1100 nM, respectively) and also suppresses NLRP3 inflammasome-mediated IL-1β release (IC50: 5 μM) . This compound exhibits antimicrobial activity against E. coli and S. aureus, making it a useful research tool for studying Wnt signaling, inflammation, and host-pathogen interactions in cellular models.
Product Specifications
CAS Number
4765-59-7
Product Name Alternative
βcatenin, Wnt, Wnt/b-catenin, Wnt/betacatenin, Wnt/β-catenin, TNKS1, TNKS2, TNKS2IN1, TNKS-2-IN-1, betacatenin, beta-catenin, Antibiotic, bcatenin, PARP
Field of Research
Epigenetics & Chromatin, Infectious Disease & Virology, Molecular Biology, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.34% (May vary between batches)
Solubility
DMSO:< 1 mg/mL (insoluble or slightly soluble)
Smiles
[O-][N+] (=O) c1ccc (cc1) -c1nc (=O) c2ccccc2[nH]1
Molecular Formula
C14H9N3O3
Molecular Weight
267.24
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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