Xanthone

Xanthone is a monoamine oxidase A (MAO-A) inhibitor with an IC50 of 0.84 µM. Xanthon inhibits Norepinephrine (HY-13715) and high-K+-induced vasoconstriction with IC50 values of 60.26 μM and 82.9 μM, respectively. Xanthon increases intracellular cyclic adenosine 3′,5′-monophosphate (cAMP) content and blocks Ca2+ channels. Xanthone is the scaffold of several pharmacologically active compounds[1][2].

Product Specifications

CAS Number

[90-47-1]

UNSPSC

12352005

Hazard Statement

H410

Target

Calcium Channel; Monoamine Oxidase

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/xanthone.html

Concentration

10mM

Purity

99.97

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

O=C1C2=C(OC3=C1C=CC=C3)C=CC=C2

Molecular Formula

C13H8O2

Molecular Weight

196.21

Precautions

H410

References & Citations

[1]Cheng YW, et al. Mechanism of vasorelaxation of thoracic aorta caused by xanthone. Eur J Pharmacol. 1997 Oct 1;336 (1) :23-8. |[2]El-Seedi HR, et al. Recent insights into the biosynthesis and biological activities of natural xanthones. Curr Med Chem. 2010;17 (9) :854-901.