FA16
FA16 is a selective and metabolically stable 2- (trifluoromethyl) benzimidazole derivative that potently induces ferroptosis by inhibiting system Xc- (IC50 = 1.26 μM) . It blocks cystine/glutamate exchange, leading to glutathione depletion and lipid peroxidation. This compound has demonstrated significant antitumor efficacy in a HepG2 xenograft model, supporting its use in researching ferroptosis-dependent cancer therapies.
Product Specifications
Product Name Alternative
FA-16, FA16, FA 16, Ferroptosis
Field of Research
Cell Biology
Purity
99.44% (May vary between batches)
Solubility
DMSO:4.69 mg/mL (10.01 mM)
Smiles
FC (F) (F) C (N=C1C2C=CC=C1) N2CC (CC3) CCN3C4=CC=C (S (N (C) C) (=O) =O) C=C4
Molecular Formula
C22H27F3N4O2S
Molecular Weight
468.54
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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