MDL-800
MDL-800 is a potent and selective SIRT6 activator, enhancing its deacetylase activity to reduce global H3K9ac and H3K56ac levels. It suppresses hepatocellular carcinoma cell proliferation in vitro through SIRT6-mediated cell-cycle arrest and demonstrates efficacy in vivo in xenograft models, supporting its use in oncology and epigenetics research.
Product Specifications
CAS Number
2275619-53-7
Product Name Alternative
MDL 800, MDL800, MDL-800, SIRT6
Field of Research
Epigenetics & Chromatin, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
SIRT6 allosteric activator
Form
Powder
Solubility
Soluble in DMSO (up to 10 mg/ml with warming)
Smiles
COC (=O) c1cc (NS (=O) (=O) c2cc (Cl) cc (Cl) c2) ccc1S (=O) (=O) Nc1cc (Br) c (F) cc1C
Molecular Formula
C21H16BrCl2FN2O6S2
Molecular Weight
626.3
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
Methyl 2- (N- (5-Bromo-4-fluoro-2-methylphenyl) sulfamoyl) -5- (3,5-dichlorophenylsulfonamido) benzoate
Available Sizes
Frequently Asked Questions
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