MTOR inhibitor 9e
The compound 9e is a potent and selective mTOR inhibitor, exhibiting an IC50 of 0.68 nM for mTOR while showing significantly lower activity against PI3Kα (IC50 = 1359 nM) . This selectivity profile makes it a valuable chemical probe for studying mTOR-dependent signaling pathways in cancer research and cellular biology, applicable in both in vitro and in vivo experimental models.
Product Specifications
CAS Number
1144075-40-0
Product Name Alternative
1 (4 (4 (8oxa3azabicyclo[3.2.1]octan3yl) thieno[3,2d]pyrimidin2yl) phenyl) 3cyclopropylurea, mTOR inhibitor 9e, mTOR, PI3Kα
Field of Research
Pharmacology & Drug Discovery; Cell Biology, Signal Transduction
Purity
98.80% (May vary between batches)
Solubility
DMSO:1 mg/mL (2.37 mM)
Smiles
N (C (NC1CC1) =O) C2=CC=C (C3=NC (=C4C (=N3) C=CS4) N5CC6OC (C5) CC6) C=C2
Molecular Formula
C22H23N5O2S
Molecular Weight
421.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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