Trans-Platinum (II) diammine dichloride

Trans-Platinum (II) diammine dichloride (trans-platinumdiamminedichloride) is a geometric isomer of Cisplatin (HY-17394) . Trans-Platinum (II) diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage while exhibiting low cytotoxicity. Trans-Platinum (II) diammine dichloride is useful for studying DNA-protein cross-links[1][2].

Product Specifications

CAS Number

[14913-33-8]

Product Name Alternative

Trans-platinumdiamminedichloride

UNSPSC

12352200

Hazard Statement

H317, H318, H334

Target

DNA Alkylator/Crosslinker

Type

Biochemical Assay Reagents

Related Pathways

Cell Cycle/DNA Damage

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/trans-platinum-ii-diammine-dichloride.html

Purity

99.90

Solubility

DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

Cl[Pt]Cl.N.N

Molecular Formula

Cl2H6N2Pt

Molecular Weight

300.05

Precautions

H317, H318, H334

References & Citations

[1]Zwelling LA, Anderson T, Kohn KW. DNA-protein and DNA interstrand cross-linking by cis- and trans-platinum (II) diamminedichloride in L1210 mouse leukemia cells and relation to cytotoxicity. Cancer Res. 1979 Feb;39 (2 Pt 1) :365-9.|[2]Kohn KW, Ewig RA. DNA-protein crosslinking by trans-platinum (II) diamminedichloride in mammalian cells, a new method of analysis. Biochim Biophys Acta. 1979 Mar 28;562 (1) :32-40.