Peptide P60
Peptide P60 (FOXP3 inhibitor P60) is a 15-mer synthetic peptide, cell-permeable inhibitor of FOXP3, binds specifically to FOXP3; inhibits murine and human-derived Treg and improves effector T cell stimulation, overcomes the inhibitory effect of FOXP3 on the activity of the transcription factors NF-κB and NFAT, inhibits upregulation of mRNA for Foxp3 and IL-10 on effector T cells and enhances mRNA for IFN-γ after anti-CD3 stimulation; induces a scurfy-like disease in newborn mice, improves vaccine efficacy in mice model of CT26 tumor and HCV infection.
Product Specifications
CAS Number
1319725-20-6
Purity
>98%
Smiles
C (C1=CNC2=CC=CC=C12) [C@H] (NC (=O) [C@H] (CCSC) NC (=O) [C@H] (CCCCN) NC (=O) [C@H] (CCCNC (N) =N) NC (=O) [C@@H] (NC (=O) [C@H] (CO) NC (=O) [C@H] (CCC (=O) N) NC (=O) [C@@H] (NC (=O) [C@H] (CC (=O) O) NC (=O) [C@@H] (N) CCCNC (N) =N) CC1C=CC=CC=1) CC1C=CC=CC=1) C (N1CCC[C@H]1C (=O) N[C@H] (C (=O) N[C@H] (C (=O) N[C@@H] (C) C (=O) N[C@H] (C (=O) O) CCSC) CC1C=CC=CC=1) CC1C=CC=CC=1) =O
Molecular Formula
C95H132N24O20S2
Molecular Weight
1994.34
Notes
For research use only.
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