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AZD4625

AZD4625 is a potent, selective, covalent allosteric inhibitor of mutant GTPase KRAS G12C with IC50 of 3 nM, inhibitor H358 cell proliferation with GI50 of 4 nM.AZD4625 is a clinical development candidate for the treatment of KRASG12C positive tumors.

Product Specifications

Purity

0.98

Smiles

C=CC (N1C[C@H]2N (C3=C4C (OCC2) =C (Cl) [C@@] ([C@@]5=C (F) C=CC=C5O) =C (F) C4=NC=N3) C[C@H]1C) =O

Molecular Formula

C24H21ClF2N4O3

Molecular Weight

486.904

Notes

For research use only.

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