NH-23-C2
NH-23-C2 (Caspase-2 inhibitor NH-23-C2) is a potent, selective and cell-permeable endogenous caspase-2 inhibitor, does not block caspase-3 or caspase-8.NH-23-C2 displays off-reactivity with cysteine and threonine proteases (cathepsins B, L, V, S) .HCT116 cells were preincubated with NH-23-C2 inhibitor, MDM-2 cleavage was inhibited in a concentration-dependent manner (IC50 =3.11 μM) .NH-23-C2 selectively block caspase-2 activity and caspase-2-mediated MDM-2 cleavage.
Product Specifications
Purity
>98%
Smiles
O=C (O) CCC[C@H] (NC ([C@H]1NC2=C (C=CC=C2) C1) =O) C (N[C@@H] ([C@H] (OCC3=CC=CC=C3) C) C (N[C@@H] (CO) C (N[C@@H] (CC (O) =O) C (COC (C4=C (C) C=CC=C4C) =O) =O) =O) =O) =O
Molecular Formula
C43H51N5O13
Molecular Weight
845.903
Notes
For research use only.
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