GPS167
GPS167 is a specific small molecule splicing regulator SRSF10 inhibitor, modulates BCLAF1 splicing with IC50 of 2 uM in human colorectal HCT116 cells, directly inhibits CLK1, CLK2 and CLK4, but not SRPK1 and DYRK1A.GPS167 promotes the dephoshorylation of SRSF10 and changes its interaction with partner proteins.GPS167 treatment leads to a partial dephosphorylation of SRSF10 and increases the recovery of CLK1 and CLK4.GPS167 impairs the growth of cancer cell line, elicits p53-dependent cytotoxicity.GPS167 is cytotoxic for human colorectal cancer organoids but not normal organoids.
Product Specifications
Purity
>97%
Smiles
O=C (C1=CSC (NC2=CC=CC=C2) =N1) NC3=CC4=C (NN=C4) C=C3
Molecular Formula
C17H13N5OS
Molecular Weight
335.385
Notes
For research use only.
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
123802-AP 100 µL
BAF57 (SWI/SNF-related Matrix-associated Actin-dependent Regulator of Chromatin Subfamily E Member 1, BRG1-associated Factor 57, SMARCE1) (AP) discontinued
Sign In for Pricing
View Details 
FG-G-001-58A 100 µL
Neuropeptide FF Receptor 1 (NPFF-1R) (185-203) (Human) - FAM Labeled Purified IgG
Sign In for Pricing
View Details