AGB1
AGB1 is a fast, highly selective, and potent bump-and-hole (B&H) -PROTAC degrader for BromoTag. AGB1 exhibits degradation for Ab:Brd4BD2 L387A and Ab: BromoTag-Brd2 with pDC50s of 7.8 and 7.9. AGB1 exhibits binary affinity to VHL (Kd=125 nM) . AGB1 exhibits favorable pharmacokinetic profile in mice with the DC50, 6 h of ∼13 nM.
Product Specifications
CAS Number
2776190-62-4
Purity
>97%
Smiles
ClC1=CC=C (C=C1) C2=N[C@H] (C3=NN=C (N3C4=C2C (C) =C (C) S4) C) [C@@H] (CC) C (OCCOCCOCCOCC (N[C@@H] (C (C) (C) C) C (N5C[C@H] (O) C[C@H]5C (NCC6=CC=C (C=C6) C7=C (C) N=CS7) =O) =O) =O) =O
Molecular Formula
C51H63ClN8O9S2
Molecular Weight
1031.68
Storage Conditions
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Notes
For research use only.
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